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Has cancer finally been beaten?

by Peter Roe, Health


Have cancer researchers finally found what they've been looking for, for so long? Will cancer soon be easily eliminated without the barbaric cut-poison-burn procedures that are currently the only options? The answers are almost certainly yes.... and no.

Yes - it really does look like researchers at Stanford University may finally have found the 'holy grail' of cancer medicine - a method of defeating cancer reliably without the side effects of surgery, chemotherapy and radiation treatments, in this case by working with the body's immune system. And No - sadly it is unlikely that this therapy will actually become available to those diagnosed with cancer, even if the human trials scheduled for 2014 are a total success.

The Stanford team, led by Dr. Irving L. Weissman of the School of Medicine, established a decade ago that all human cancer cells studied have high levels of a protein called CD47 attached to their cell membranes, and that this protein acts to protect the cells from being attacked by the body's immune system. In a stunning breakthrough the team has recently managed to develop an antibody to CD47 that blocks formation of the protein and so strips the cancer cells of their 'stealth' protection. The team discovered that when the 'naked' cells are then recognised by macrophages, and are subsequently destroyed by the body's 'hunter-killers' - the CD8+ T-cells. Even more exciting is the discovery that once the killer T cells had killed a cancer cell, they unexpectedly went on to recognise and kill more cancer cells of the same type, even when these had not been 'marked' by macrophages.

In tests on laboratory mice infected with a wide range of human cancers including liver, prostate, breast, ovarian, colonic, brain and bladder, the anti-CD7 antibody successfully cleared all the test animals of cancer cells by allowing their immune systems to 'see' and destroy them. Even after the cells had been allowed to multiply to form tumours, the antibody either allowed macrophages to destroy the cancer, or stopped tumour growth and prevented metatstasis (spreading to other sites). There seems to be no reason to expect that the system will not work similarly in human volunteers in the phase 1 clinical trials scheduled for 2014 and funded by the California Institute for Regenerative Medicine.

BUT - several very hopeful anti-cancer discoveries have already failed to find any backing from big pharma over the last few decades, and so have been lost or ignored, and various apparently effective 'alternative' remedies such as hemp oil, lithium carbonate, hyperbaric oxygen, megadose ascorbic acid, and sugar-bicarbonate have not only failed to attract any serious research, but are routinely suppressed by corrupt officials or ridiculed by paid shills online in order to remove potential competition from expensive and largely ineffectual drugs.  The money-raising machines that are the 'cancer charities' likewise ignore many potential cures in their cynical 'war on cancer', because a successful cure would end the money stream and also their reason for existing. If the new antibody treatment shows even modest signs of success, history suggests that it too will be ruthlessly suppressed by whatever means are necessary, or priced beyond the reach of anyone except the extremely rich.


Primary source:

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11103-8. doi: 10.1073/pnas.1305569110. Epub 2013 May 20.

Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response.

Tseng D, Volkmer JP, Willingham SB, Contreras-Trujillo H, Fathman JW, Fernhoff NB, Seita J, Inlay MA, Weiskopf K, Miyanishi M, Weissman IL

Institute for Stem Cell Biology and Regenerative Medicine and the Ludwig Cancer Center, Stanford University Medical Center, Stanford, CA 94305.


Keywords: Irving Weissman, CD47, anti-cancer, antitumour, antitumor, Stanford School of Medicine



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