Cyclamate

Cyclamate was in use until 1969 as an artificial sweetener in the United States and Canada, until its use was banned by the US FDA after reports that large quantities of cyclamates could cause liver damage, bladder cancer, birth mutations and defects. It also reduces testosterone and can shrivel the testes. Of course, this rather begs the question of how it came to be approved for human consumption in the first place.

It is still available without restriction in the UK and Europe where apparently such side effects are acceptable by the ‘authorities’. As cyclamate is stable in heat, it was and is marketed as suitable for use in cooking and baking. Commercially, it is available as Sucaryl™.