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Calcium glucarate

(calcium d-glucarate, calcium saccharate, d-glucaro-1,4-lactone, Antacidin, saccharated lime)

 

Glucaric acid is an important nutrient found principally in cruciferous vegetables (broccoli, sprouts, cabbage etc.), green beans and apples. Calcium glucarate is the stable calcium salt of glucaric acid which is used for supplementation.

Some preliminary studies indicate that glucaric acid may decrease cholesterol levels and protect against kidney damage caused by certain antibiotics. Further studies are required to confirm and explain these observations.

Glucaric acid and its salts are also known to be important in the deactivation and removal of toxins* from the body during a metabolic process called glucuronidation. This process takes place in the liver, where glucoronic acid is attached to toxic molecules, rendering them water soluble. They are then excreted in the bile, which is discharged to the gut so the toxins may be excreted. Unfortunately some gut bacteria produce significant amounts of beta-glucuronidase, an enzyme which breaks the link between the toxin molecules and glucoronic acid, releasing the toxins into the gut from where they are likely to be re-absorbed before they can be excreted. Higher than normal gut levels of beta-glucuronidase are associated with an increased risk for various cancers, particularly hormone-dependent cancers like breast, prostate, and colon cancer.

Calcium d-glucarate has been shown to inhibit beta-glucuronidase, and studies in animals have shown that calcium d-glucarate supplementation at high dose rates prevents the development of experimentally induced cancers. Additionally, glucaric acid interferes with the re-absorption of estrogen from the gut, causing more estrogen to be eliminated and reducing blood levels.

High estrogen levels have been associated with the development and growth of breast, colon, and prostate cancers, and calcium glucarate is sometimes taken in an effort to control such cancers. There is so far no sound evidence for its effectiveness in this context, but in view of its lack of toxicity and the fact that there are no known drug interactions, and also its relative cheapness, it is increasingly widely used in this way.

Manufacturers of calcium glucarate supplements generally recommend a daily intake of 200 to 400 mg but higher levels will be easily tolerated by most people.

 

* Toxins that are known to be processed by glucuronidation include nitrosamines produced by meat processing and high temperature cooking, PTFE residues from non-stick pans, fungal toxins, e.g. aflatoxin in peanuts and Herxheimer breakdown products from ‘die back’ of candida albicans, mercury from dental fillings, pesticide residues, and a wide range of other organic toxins originating from plastics, paints, solvents, cleaners and even ‘body care’ products.

 

 

 

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